Results Report 2022 At a glance

50 million lives saved

By the end of 2021, programs supported by the Global Fund partnership had saved 50 million lives. Since 2002, we have cut the combined death rate from AIDS, tuberculosis (TB) and malaria by more than half. Every life saved, and every infection averted, has a multiplier effect across families, communities and entire nations. Our fight against the deadliest infectious diseases is led by the diverse actors who comprise the Global Fund partnership – communities, governments, the private sector, civil society and our technical partners. Together, we have made tremendous progress. But our fight isn’t over. Colliding crises – conflict, climate change, COVID-19 and other global health challenges – threaten to knock us backward. We must continue to invest in efforts to accelerate progress toward a world free of AIDS, TB and malaria while supporting countries to better prepare for future pandemics.

State of the fight


The Global Fund provides 30% of international financing for HIV programs. In countries where the Global Fund invests, AIDS-related deaths reduced by 70% between 2002 and 2021. The percentage of people in need of antiretroviral therapy who received it significantly increased over the past decade, from 23% in 2010 to 75% in 2021. While COVID-19 interrupted
HIV services, the Global Fund partnership fought back. In countries where we invest, HIV testing services for groups in greatest need as well as prevention services started to recover in 2021.



The Global Fund provides 76% of international financing for TB programs. In countries where the Global Fund invests, TB deaths (excluding people living with HIV) dropped by 21% between 2002 and 2020. Together with
technical partners and implementing countries, the Global Fund continues to spearhead approaches to accelerate testing and treatment for TB and to identify more “missing” people with TB. Thanks to interventions by the Global Fund partnership, TB programs began to recover in 2021 from the impact of the COVID-19 pandemic, with gains in the number of people on treatment for TB.



The Global Fund provides 63% of international financing for malaria programs. In countries where the Global Fund invests, malaria deaths
reduced by 26% between 2002 and 2020. In 2021, we continued to make
progress in offering malaria prevention services such as mosquito nets and
seasonal malaria chemoprevention to more people at risk of the disease. In
2021, Global Fund-supported programs recovered from declines in 2020,
with testing and treatment for malaria registering gains.


Key results in 2021

Strengthening systems for health

Resilient and sustainable systems for healthunderpin our efforts to defeat today’s infectious diseases and respond to future
threats. The Global Fund is the world’s largest multilateral provider of grants for strengthening systems for health. Over the 2021-2023 implementation period, we are investing US$4.9 billion, or US$1.5 billion a year, in formal and community health systems through our core grants and through our COVID-19 Response Mechanism (C19RM) – about one-third
of our total investments. In many countries, health systems
including community systems built to fight HIV, TB and malaria have been pivotal in the response to COVID-19. These
systems made a remarkable difference in the fight against the pandemic and in mitigating the knock-on impact on other diseases. By continuing to strengthen underlying systems and capacities, we can defeat today’s diseases and prepare for future ones.


Fighting COVID-19 and other crises

To end HIV, TB and malaria as public health threats and address emerging dangers to global health security, we need to reach the most vulnerable people with prevention and treatment services, wherever they are. That means directing a sharper focus on challenging operating environments
– countries or regions that experience infectious disease outbreaks, natural
disasters, armed conflicts or civil unrest, weak governance, climate change-related crises and/or mass displacement.

To mitigate the impact of COVID-19 on HIV, TB and malaria, the Global Fund has awarded more than US$4.4 billion through C19RM, along with grant flexibilities. This funding enabled countries to rapidly adapt existing programs, purchase personal protective equipment, diagnostics and
medical supplies, and deploy prevention campaigns. This rapid response helped us save lives from COVID-19 and prevent a surge in deaths from AIDS, TB and malaria.


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